Brand

Biossance

Biossance was founded in 2016 as a consumer skincare arm of Amyris, a publicly traded biotechnology company that developed sugarcane-derived squalane through synthetic biology. The brand brings genuine biotech credentials to clean beauty — its squalane production technology was originally developed in partnership with the Gates Foundation for pharmaceutical applications. Biossance has been operating for nearly a decade with a growing body of clinical testing on its formulations.

In Catalog
9
products reviewed
82/100 Score
No.1
Biossance Squalane + Omega Repair Cream in signature green glass jar Barrier Repair Gold Standard
Biossance moisturizer

Squalane + Omega Repair Cream

A beautifully formulated barrier repair cream that combines biotech-grade squalane, ceramide NP, and omega fatty acids in one of the cleanest ingredient lists you will find at Sephora. Genuinely effective for dry and sensitive skin, though the $60 price tag asks you to pay a premium for purity over complexity.

drynormal Fragrance Free
★★★★★
4.6 (4,500)
$60.00
78/100 Score
No.2
Biossance Squalane + Zinc Sheer Mineral Sunscreen SPF 30 in a white squeeze tube Clean Beauty SPF Pick
Biossance sunscreen

Squalane + Zinc Sheer Mineral Sunscreen SPF 30

A thoughtfully formulated mineral sunscreen that actually solves the problems mineral sunscreens are known for — the squalane-infused base delivers genuine hydration instead of chalky dryness, and the white cast is impressively controlled for 14% zinc oxide. Best for dry and sensitive skin types who want clean ingredients without compromising on wearability.

drynormal Fragrance Free
★★★★★
4.2 (3,000)
$34.00
73/100 Score
No.3
Biossance Squalane + Vitamin C Dark Spot Serum in a white pump bottle Clean Beauty Brightener
Biossance serum

Squalane + Vitamin C Dark Spot Serum

A thoughtfully engineered vitamin C serum that prioritizes stability and gentleness over brute-force potency. The triple-brightening approach through ethyl ascorbic acid, shiitake mushroom, and licorice root delivers real results for mild to moderate hyperpigmentation, though those with deep pigmentation may want something stronger. Excellent for sensitive skin types who have been burned by harsh vitamin C serums.

normalcombination Fragrance Free
★★★★★
4.4 (910)
$68.00
71/100 Score
No.4
Biossance Squalane + Marine Algae Eye Cream in a small green glass jar Clean Beauty Eye Award Winner
Biossance eye-cream

Squalane + Marine Algae Eye Cream

A beautifully formulated, award-winning clean eye cream that delivers genuine anti-aging actives without retinoids, fragrance, or common irritants. The paracress, peptide, and marine algae trio provides multi-pathway wrinkle care that is pregnancy-safe and NEA-accepted. The $56 price for half an ounce is the only real argument against it — and it is a strong one.

drynormal Fragrance Free
★★★★★
4.4 (700)
$56.00
69/100 Score
No.5
Biossance Squalane + Peptide Eye Gel in a white airless pump bottle Clean De-Puffing Pioneer
Biossance eye-cream

Squalane + Peptide Eye Gel

A sophisticated multi-peptide eye gel that became Sephora's best-seller for good reason — the dual-peptide, niacinamide, and vitamin C formula addresses puffiness, dark circles, and fine lines simultaneously with zero fragrance and pregnancy safety. The $54 price for 0.5 oz remains steep, and the product's apparent phase-out adds an asterisk, but the formulation itself is genuinely excellent.

normalcombination Fragrance Free
$54.00
69/100 Score
No.6
Biossance Squalane + Probiotic Gel Moisturizer in a green glass jar Clean Microbiome Innovator
Biossance moisturizer

Squalane + Probiotic Gel Moisturizer

A genuinely innovative microbiome-focused moisturizer that goes beyond 'probiotic' as a marketing buzzword. The 2023 reformulation with encapsulated multi-strain cultures, paired with squalane and calming bisabolol, delivers meaningful skin-soothing and barrier-supporting results for oily, combination, and reactive skin types. The $54 price and jar packaging are the main compromises in an otherwise impressive clean formulation.

oilycombination Fragrance Free
★★★★★
4.3 (1,000)
$54.00
63/100 Score
No.7
Biossance Squalane + Tea Tree Balancing Oil in a frosted glass dropper bottle Clean Beauty Blemish Fighter
Biossance oil

Squalane + Tea Tree Balancing Oil

A clever concept — tea tree acne treatment delivered in a skin-identical squalane base — that proved oily skin and face oils aren't enemies. The formula is minimal but intentional, though the lavender oil inclusion and now-discontinued status limit its reach. For those who snagged it, it was a genuinely effective blemish-balancing oil.

oilycombination Paraben Free
★★★★★
4.2 (450)
62/100 Score
No.8
Biossance Squalane + Vitamin C Rose Oil in a clear glass dropper bottle with golden oil Clean Beauty Glow Getter
Biossance oil

Squalane + Vitamin C Rose Oil

Seven ingredients, one cult following, and a price tag that dares you to question it. Biossance's global best-seller delivers genuine radiance through an oil-soluble vitamin C in a squalane base, and the texture is undeniably beautiful. But at seventy-four dollars for what is essentially fancy squalane with vitamin C and rose, you are paying a steep clean-beauty tax for simplicity.

drynormal Paraben Free
★★★★★
4.7 (2,800)
$74.00
61/100 Score
No.9
Biossance Squalane + BHA Pore Minimizing Toner in a green glass bottle Clean Beauty BHA Pick
Biossance toner

Squalane + BHA Pore Minimizing Toner

A well-intentioned clean beauty BHA toner that prioritizes gentleness and moisturization over raw exfoliating power. The squalane-infused formula genuinely prevents the stripping sensation common to acid toners, and the dual-BHA approach works well for mild congestion. But at $32, you are paying a premium for the clean positioning and essential oils that ironically limit who can use it.

oilycombination Paraben Free
★★★★★
4.3 (400)
$32.00
Search