Senté

Senté is a clinical skincare brand founded in 2013 by glycobiology researcher Alice Chang and her team, built around the patented Heparan Sulfate Analog (HSA) technology originally developed in academic biotech. The brand is distributed primarily through medical spas and dermatology offices, and its formulations are backed by published peer-reviewed research on HSA.

2 products reviewed

83/100 Score

Senté Even Tone Retinol Cream 30ml airless tube — clinical 0.5% encapsulated retinol with heparan sulfate analog

Derm Office Retinol

Senté retinoid

Even Tone Retinol Cream

A genuinely sophisticated clinical retinol cream that justifies its medical-spa pricing for the specific user it is built for — someone with hyperpigmentation who has struggled to tolerate standard retinol products. 0.5 percent encapsulated retinol, Senté's patented Heparan Sulfate Analog, hydroxymethoxyphenyl decanone brightening, and a ceramide-fatty acid barrier base. It is not a cream for casual shoppers, but for clinical-tier tone work, it is one of the better options available.

normalcombination Fragrance Free

Clinical HSA Eye Cream

Senté eye-cream

Illuminé Eye Cream

A sophisticated clinical-tier eye cream built around Senté's patented Heparan Sulfate Analog, dual peptides, niacinamide, and a deliberately sensitive-skin-friendly vehicle. The formulation is genuinely differentiated, the tolerability is excellent, and the results are visible but subtle. The $85 price tag is the main friction point and positions it firmly as a clinical or medical-spa purchase rather than an impulse buy.

normaldry Fragrance Free

★★★★★

4.5 (420)

$85.00