iS Clinical

iS Clinical was co-founded in 2002 by biochemist Bryan Johns and Alec Call. The brand is rooted in pharmaceutical-grade formulation and is distributed thro

14 products reviewed

82/100 Score

iS Clinical Cleansing Complex clear gel cleanser bottle with pump

Universal Daily Cleanser

iS Clinical cleanser

Cleansing Complex

The cleanser that convinced a generation of skincare professionals that the washing step should be doing more than washing. Its gentle surfactant system, dual botanical acids, and centella soothing complex deliver genuine daily maintenance in under 60 seconds, though the DMDM hydantoin preservative may give ingredient-conscious consumers pause.

oilycombination Fragrance Free

Dermatologist's Daily SPF

iS Clinical sunscreen

Eclipse SPF 50+

A mineral sunscreen that finally solved the elegance problem — lightweight, matte, and virtually invisible on the skin while delivering SPF 50+ protection from mineral filters alone. The iron oxides add visible light protection that most sunscreens ignore, making it particularly valuable for hyperpigmentation-prone skin, though the low zinc oxide concentration may concern UV purists.

normalcombination Fragrance Free

Maximum Mineral Protection

iS Clinical sunscreen

Extreme Protect SPF 40

The muscle car of mineral sunscreens — 15.3% zinc oxide means serious UV protection with a centella treatment complex that actively repairs while it shields. The richer texture sacrifices the featherweight elegance of Eclipse for moisturizing substance that dry and post-procedure skin craves, though oily types will find it too much and the $92 price is a real commitment.

drynormal Fragrance Free

Clinical Eye Treatment Powerhouse

iS Clinical eye-cream

Youth Eye Complex

One of the most ingredient-dense eye treatments on the market, deploying triple-peptide technology, DNA-protective Extremozymes, vitamin K, and a full vitamin complex in a single elegant formula. It approaches periorbital aging with the kind of biochemical sophistication that justifies its clinical positioning — if not quite its eye-watering price tag.

normaldry Fragrance Free

Minimalist Eye Essential

iS Clinical eye-cream

C Eye Serum Advance+

A beautifully stripped-down eye treatment that delivers pharmaceutical-grade vitamin C and copper peptide in just 10 ingredients. The extreme economy of use — one drop for both eyes — makes the $75 price tag genuinely reasonable, and the minimalist approach means fewer chances for the delicate eye area to react badly.

normalcombination Fragrance Free

Warming Honey Cleanser

A genuinely luxurious cleanser that uses 40% honey, papaya enzymes, and bee-derived actives to turn your evening cleanse into a spa-grade treatment. It is the rare clinical product that prioritizes the experience as much as the efficacy — and manages to deliver both.

normaldry Fragrance Free

Barrier Repair Workhorse

iS Clinical moisturizer

Reparative Moisture Emulsion

A genuinely sophisticated moisturizer that reaches beyond the usual peptide-and-hyaluronic-acid playbook to include resurrection plant DNA-repair enzymes and enzymatic antioxidants. The formula earns its clinical pedigree with a level of ingredient complexity you rarely see outside of a compounding pharmacy — if you can stomach the price.

drynormal Fragrance Free

Clinical Scar Treatment Hero

iS Clinical serum

Super Serum Advance+

iS Clinical's most ambitious serum delivers 15% L-ascorbic acid alongside the GHK copper peptide fragment and isolated centella triterpenoids in an alcohol-free base that's gentler than you'd expect at this potency. It's the rare vitamin C serum with a legitimate scar-treatment application, and its clean formula earns the 'super' in the name — even if the price earns a raised eyebrow.

normalcombination Fragrance Free

Post-Procedure Pro Favorite

iS Clinical serum

Hydra-Cool Serum

A beautifully minimalist hydrating serum that earns its place in derm offices for good reason — isolated centella triterpenoids and hyaluronic acid deliver genuine soothing and hydration in a formula so clean it barely needs a label. The price-per-ounce is steep, but if your skin is reactive, post-procedure, or rosacea-prone, this is the kind of product that justifies its clinical pedigree.

sensitivecombination Fragrance Free

Cult-Classic Multitasker

iS Clinical serum

Active Serum

The Swiss Army knife of facial serums — twelve ingredients, zero filler, and a track record spanning two decades of dermatologist endorsement. The tri-acid botanical blend genuinely delivers on acne, pigmentation, and texture simultaneously, but the price and irritation potential mean this is a targeted weapon, not an everyday moisturizer replacement.

oilycombination Fragrance Free

Luxury Anti-Aging Icon

iS Clinical moisturizer

Youth Intensive Crème

iS Clinical's most ambitious moisturizer throws nearly every anti-aging strategy into a single luxurious jar — copper peptides, superoxide dismutase, stabilized vitamin C, centella triterpenoids, botanical AHAs, and soy isoflavones. It is a formulation tour de force that delivers real results for aging skin, tempered only by its eye-watering price and citrus essential oils that exclude sensitive types.

drynormal Paraben Free

Multi-Vitamin Powerhouse

iS Clinical serum

Poly-Vitamin Serum

A sophisticated multi-vitamin serum that combines retinol, niacinamide, AHAs, and antioxidants in one elegantly stripped-down formula. It's the kind of product that respects your skin's intelligence enough to feed it a complete nutritional profile rather than hammering it with one active. The price stings, but the formulation earns it.

normalcombination Fragrance Free

Hydroquinone-Free Brightener

iS Clinical serum

White Lightening Serum

A hydroquinone-free brightening serum that tackles hyperpigmentation from three biochemical angles — tyrosinase inhibition, melanin transfer blocking, and accelerated cell turnover. The clinical data showing 75% pigmentation reduction at 12 weeks is impressive, though the $152 price and denatured alcohol content temper the enthusiasm.

normalcombination Fragrance Free

Clinical Vitamin C Gold Standard

iS Clinical serum

Pro-Heal Serum Advance+

A serious vitamin C serum built for people who want clinical-grade results, not Instagram aesthetics. The 15% L-ascorbic acid combined with retinol, arbutin, and anti-inflammatory botanicals creates one of the most comprehensive treatment serums on the professional market — if your budget and skin tolerance can handle it.

normaloily Fragrance Free

★★★★★

4.6 (500)

$177.00