No. 9 NAD+ Retinol Volumetox Eye Cream

The longevity crowd knows NAD+ well. Nicotinamide adenine dinucleotide — a coenzyme that powers cellular energy production and DNA repair — has been the darling of the supplement world for years, championed by researchers studying aging at the molecular level. As we age, NAD+ levels decline, and the theory goes that replenishing them could slow or reverse aspects of cellular aging. Oral supplements, IV infusions, and NAD+ precursors like NMN have built a billion-dollar industry around this idea. Numbuzin is now asking a different question: what if you put NAD+ directly on the skin?

It's a bold proposition, and honesty requires saying upfront that the evidence for topical NAD+ delivery is still emerging. The molecule is large and doesn't penetrate the skin easily. The studies supporting NAD+ as an anti-aging intervention are primarily based on oral or intravenous supplementation, not topical application. Numbuzin doesn't disclose the NAD+ concentration, and independent studies on topical NAD+ in skincare are sparse. If NAD+ were the only active in this formula, healthy skepticism would be warranted.

But NAD+ isn't carrying this formula alone — it's part of an ensemble cast that would be impressive at three times the price. Niacinamide appears high in the ingredient list, and here's where the science gets interesting: niacinamide is a direct precursor to NAD+ within the skin. The body converts niacinamide to NAD+ through the salvage pathway, and this conversion is well-documented. By including both the end product (NAD+) and its most efficient precursor (niacinamide), Numbuzin has created a dual-pathway approach — supplying NAD+ directly while also boosting the skin's own production. Whether the topical NAD+ penetrates meaningfully or not, the niacinamide pathway is well-established.

Then there's the retinol. Positioned lower in the ingredient list, the concentration is likely gentle — appropriate for the periorbital area where skin is up to ten times thinner than the rest of the face. Retinol's ability to stimulate collagen production and accelerate cell turnover is among the most validated claims in all of dermatology. Even at low concentrations, consistent nightly application produces measurable improvement in fine lines around the eyes over 8-12 weeks.

The peptide complex is where the formula starts to feel almost unreasonably ambitious for its price point. Over thirty peptides, including Acetyl Tetrapeptide-5 — marketed as EYESERYL, specifically researched for under-eye puffiness through its ability to reduce fluid accumulation — and Copper Tripeptide-1, which has genuine evidence for stimulating collagen, elastin, and glycosaminoglycan production. Multiple palmitoyl peptides target wrinkle depth and skin firmness through signal peptide mechanisms. Is every one of these thirty peptides present at an efficacious concentration? Almost certainly not. But even a handful of them working at mild levels, combined with the retinol and niacinamide, adds up to a multi-pronged approach that most eye creams in this price range don't even attempt.

The vehicle is smart too. Ceramide NP with cholesterol provides barrier support for the fragile eye area. Three forms of hyaluronic acid — regular, hydrolyzed, and sodium hyaluronate — deliver multi-depth hydration. Macadamia and olive oils provide rich emolliency, and shea butter adds occlusive weight without heaviness. The texture lands in a sweet spot: substantial enough to feel like a real treatment, not so heavy that it migrates into the eyes during sleep.

Users have responded well. Over 840 reviews on Numbuzin's own site, with consistent praise for the gentle retinol that doesn't sting, the immediate brightening effect under the eyes, and the rich-but-not-greasy texture. The complaint about the 10 mL size is universal and valid — this is a very small tube, and even with the tiny amounts needed for the eye area, it'll last about six to eight weeks. At $21, the monthly cost is reasonable, but you'll feel the smallness of the tube every time you squeeze it.

The brand deserves credit for ambition, even if the NAD+ claim outpaces the evidence. Numbuzin's founders cut their teeth at Amorepacific — Korea's largest beauty company — and their formulation approach reflects that training: layer multiple mechanisms at gentle concentrations rather than betting everything on a single hero ingredient at a high dose. It's a philosophy that reduces risk of irritation while increasing the chances that at least several actives are doing meaningful work.

For the price, this eye cream offers more ingredient complexity than products costing three to five times as much. The retinol, niacinamide, ceramide, and peptide layers are all well-validated individually. The NAD+ is the speculative cherry on top — potentially meaningful, but not yet proven for topical use. If you approach this product as an excellent retinol-niacinamide-peptide eye cream with an intriguing NAD+ addition, rather than a NAD+ eye cream with some supporting ingredients, you'll set your expectations accurately and likely be very satisfied with the results.

Formula

The hero actives that drive this product's performance.

Ingredient	Function	Evidence
Retinol	The gold standard anti-aging active, included here to stimulate collagen production and accelerate cell turnover in the thin, wrinkle-prone periorbital skin. Positioned lower in the ingredient list, the retinol concentration is likely gentle enough for daily eye-area use — appropriate for the delicate skin that is thinner and more reactive than the rest of the face.	well-established
Nicotinamide Adenine Dinucleotide (NAD+)	A coenzyme central to cellular energy metabolism and DNA repair. NAD+ levels decline with age, and topical application is positioned to support cellular repair processes in the periorbital area. While oral NAD+ supplementation has substantial research behind it, topical delivery to the skin is an emerging area — this is the formula's most novel but least proven ingredient.	emerging
Niacinamide	Positioned high in the ingredient list, niacinamide addresses dark circles through its brightening mechanism while supporting ceramide synthesis in the skin barrier. In the context of this eye cream, it works synergistically with the NAD+ — niacinamide is actually a precursor to NAD+ in the skin, so their co-inclusion creates a dual-pathway approach to cellular energy support.	well-established
Ceramide NP	Reinforces the fragile barrier of the periorbital skin, which is particularly susceptible to moisture loss and irritation. Combined with cholesterol in the formula, it provides structural lipid support that helps the eye area retain hydration and resist the mild irritation that retinol can cause.	well-established
Peptide Complex (30+ peptides)	An extensive peptide blend including Acetyl Tetrapeptide-5 (EYESERYL — targets under-eye puffiness by reducing fluid accumulation), Copper Tripeptide-1 (stimulates collagen and elastin synthesis), and multiple palmitoyl peptides targeting wrinkle depth and skin firmness. The sheer breadth of the peptide complex is this formula's most distinctive feature, targeting multiple signs of eye aging simultaneously.	promising

Full INCI List

Water, Butylene Glycol, Glycerin, Propanediol, Macadamia Integrifolia Seed Oil, Niacinamide, Olea Europaea (Olive) Fruit Oil, Cetyl Ethylhexanoate, Methylpropanediol, Butyrospermum Parkii (Shea) Butter, Methyl Hydrogenated Rosinate, Polysorbate 60, Cyclopentasiloxane, 1,2-Hexanediol, Cetyl Alcohol, Stearic Acid, Glyceryl Stearate SE, Glyceryl Stearate, Dimethicone, PEG-100 Stearate, Cyclohexasiloxane, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/VP Copolymer, Sorbitan Stearate, Behenic Acid, Cocos Nucifera (Coconut) Oil, Hydroxyacetophenone, Polyacrylate-13, Vinyl Dimethicone, Behenyl Alcohol, Dimethicone/Vinyl Dimethicone Crosspolymer, Phytosteryl Isostearate, Polyisobutene, Ceramide NP, Nicotinamide Adenine Dinucleotide, Caprylic/Capric Triglyceride, Citric Acid, Retinol, Ethylhexylglycerin, Polyglyceryl-4 Oleate, Adenosine, Hydrolyzed Gardenia Florida Extract, Hydrolyzed Malt Extract, Hydrolyzed Viola Tricolor Extract, Theobroma Cacao (Cocoa) Seed Extract, Canola Sterols, Polysorbate 20, Disodium EDTA, Sorbitan Isostearate, Dextrin, Cholesterol, Polyglyceryl-10 Laurate, Ammonium Polyacryloyldimethyl Taurate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Aluminum/Magnesium Hydroxide Stearate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Potassium Cetyl Phosphate, Hydroxypropyl Cyclodextrin, Chitosan, Tris(Tetramethylhydroxypiperidinol) Citrate

Product Flags

✓ Fragrance Free✓ Alcohol Free✗ Oil Free✗ Silicone Free✓ Paraben Free✓ Sulfate Free✓ Cruelty Free✗ Vegan✗ Fungal Acne Safe

Potential Irritants

Retinol

Compatibility

Best For

normal dry combination

Works For

sensitive oily

Not Ideal For

Addresses These Conditions

aging dark circles dullness

Use With Caution

sensitivity

Routine Step

treatment

Time of Day

PM

Pregnancy Safe

No ✗

Layering Tips

Apply as the dedicated eye treatment step, after serums and before moisturizer. Use your ring finger to gently pat a small amount along the orbital bone, from the inner corner outward. Can be used in the morning as well if your skin tolerates retinol during the day — just ensure SPF application afterward. Avoid layering with additional retinoids on the same area.

Results Timeline

Immediate hydration and a smoother, more luminous under-eye area from the first application. Visible improvement in fine lines and dark circles typically emerges at 4-6 weeks. Firming and volumizing effects from the peptide complex develop over 8-12 weeks of consistent nightly use.

Pairs Well With

Hydrating serumCeramide moisturizerSPF 30+ (morning after)

Conflicts With

Additional retinoids applied to the eye areaStrong AHA/BHA products near the eye area

Sample AM Routine

1. Gentle cleanser
2. Hydrating toner
3. Vitamin C serum
4. Moisturizer
5. SPF 30+

Sample PM Routine

1. Gentle cleanser
2. Hydrating toner
3. Serum
4. Numbuzin No. 9 NAD+ Retinol Volumetox Eye Cream
5. Moisturizer

Evidence

The Science

The NAD+ angle in this formula represents one of skincare's newer frontiers. NAD+ (nicotinamide adenine dinucleotide) is essential for mitochondrial energy production and activates sirtuins — a family of enzymes involved in DNA repair, inflammation regulation, and cellular stress resistance. A landmark paper published in Cell by Imai and Guarente in 2014 established that declining NAD+ levels are a hallmark of aging, with implications for virtually every tissue including the skin. However, most NAD+ research focuses on oral supplementation or intravenous delivery; published evidence for topical NAD+ penetration and efficacy in human skin remains limited.

The inclusion of niacinamide alongside NAD+ is biochemically sound. Niacinamide feeds the NAD+ salvage pathway via the enzyme NAMPT (nicotinamide phosphoribosyltransferase), and studies published in the Journal of Investigative Dermatology have confirmed that topical niacinamide at concentrations of 2-5% increases ceramide and free fatty acid synthesis in the stratum corneum while providing measurable brightening and barrier-strengthening effects.

The peptide complex includes Acetyl Tetrapeptide-5 (EYESERYL), which has been studied for its anti-edema properties around the eye. In vitro studies show it reduces glycation of proteins and decreases vascular permeability, which contributes to reducing under-eye puffiness and dark circles caused by fluid accumulation. Copper Tripeptide-1 (GHK-Cu) has a stronger evidence base, with published research in the Journal of Biomedicine and Biotechnology demonstrating its ability to stimulate collagen synthesis, attract immune cells for tissue repair, and possess antioxidant activity — though most studies use concentrations higher than what's likely present in this multi-peptide formula.

Dermatologist Perspective

Board-certified dermatologists note that retinol remains one of the most validated topical anti-aging ingredients for the periorbital area, and its inclusion in a gentle, well-buffered eye cream is clinically sound. Dermatologists typically advise starting with low-concentration retinol around the eyes and increasing gradually, which this product's formulation appears to support. The NAD+ component draws interest from dermatologists following the longevity science, though most recommend focusing on the proven ingredients — retinol, niacinamide, and peptides — when setting patient expectations. The ceramide and hyaluronic acid support is appreciated from a clinical standpoint for maintaining barrier integrity in the thin periorbital skin.

Guidance

How to Use

Apply a rice-grain-sized amount to the under-eye area and orbital bone each evening, after serums and before moisturizer. Use your ring finger — it applies the least pressure — to gently pat the cream from the inner corner outward along the orbital bone. Avoid applying directly to the eyelid or lash line. Can also be used in the morning; if so, always apply SPF afterward. For best results, use consistently every night for a minimum of 8-12 weeks before evaluating wrinkle and dark circle improvement.

Value Assessment

At $21 for 10 mL, the per-milliliter cost is $2.10 — higher than a facial moisturizer but competitive for a dedicated eye cream. The ingredient complexity at this price point is remarkable: retinol, NAD+, 30+ peptides, niacinamide, ceramide NP, three forms of hyaluronic acid, shea butter, and multiple botanical extracts. Comparable ingredient lists from Western clinical brands typically command $50-100 for similar or smaller sizes. The main value concern is the small tube size — upgrading to a 15-20 mL format at a slightly higher price would significantly improve the value perception.

Who Should Buy

Anyone looking for a multi-functional eye cream that addresses fine lines, dark circles, puffiness, and loss of firmness simultaneously without spending luxury-brand prices. Particularly well-suited for K-beauty enthusiasts who appreciate complex, multi-active formulations and for users new to retinol around the eyes who want a gentle entry point.

Who Should Skip

Pregnant or breastfeeding individuals should avoid this due to the retinol content. Those looking for high-concentration retinol for advanced wrinkle correction may find this too gentle — the retinol level appears designed for maintenance and prevention rather than aggressive treatment. If you're skeptical of emerging ingredients and prefer formulas with only extensively validated actives, the NAD+ component may not appeal.

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Details

Texture

A rich, velvety cream that feels substantial without being heavy. Glides on smoothly with gentle patting and absorbs well without leaving an oily film. The silicone base gives it a silky, skin-smoothing feel.

Scent

Fragrance-free with no noticeable scent.

Packaging

A small 10 mL tube with a narrow applicator tip for precise dispensing. The compact size is travel-friendly but makes the per-use cost feel steep.

Finish

satinnon-greasyvelvety

What to Expect on First Use

On first use, the cream feels rich and immediately hydrating. No tingling or irritation from the retinol — the concentration appears gentle enough for the eye area. The under-eye area looks slightly brighter and more plumped after the first application, likely from the hyaluronic acid and emollient complex. No adjustment period or peeling expected.

How Long It Lasts

6-8 weeks with twice-daily use on both eyes

Period After Opening

12 months

Best Season

All Year

Background

Numbuzin's No. 9 series targets 'volume and wrinkle care' — the most advanced anti-aging category in their numbered system. This eye cream represents the brand's ambition to bring cutting-edge ingredients like NAD+ to K-beauty's accessible price tier. The formulation reflects the founders' Amorepacific training: layer multiple mechanisms at gentle concentrations rather than relying on a single hero ingredient at aggressive levels.

About Numbuzin Emerging Brand (2–5 years)

Numbuzin was launched in 2019 by Benow, a South Korean beauty startup co-founded by Lee Il-joo and Kim Dae-young, both Seoul National University alumni and former Amorepacific employees. The brand won top honors at the 2022 Olive Young Awards and has expanded to 16 countries. Its numbered product system is designed for simple, goal-based skincare routines.

Brand founded: 2019 · Product launched: 2024

Myth vs. Reality

Myth

Eye creams are just expensive moisturizers — your regular cream works fine around the eyes.

Reality

The periorbital skin is 10 times thinner than the rest of the face, has fewer oil glands, and shows aging signs earlier. This eye cream is specifically formulated with EYESERYL peptide for under-eye puffiness and retinol at a concentration calibrated for the thinner, more reactive eye-area skin — features that a general moisturizer doesn't address.

Myth

Retinol is too harsh for the eye area.

Reality

Retinol concentration matters more than the ingredient itself. This formula uses retinol at a level positioned well below the high-actives in the ingredient list, suggesting a gentle concentration appropriate for periorbital use. The ceramide and niacinamide in the formula further buffer any potential irritation.

FAQ

Common Praise

"Gentle retinol that doesn't irritate the eye area"

"Rich but not heavy texture"

"Visible improvement in under-eye brightness"

"Good value for the ingredient complexity"

"No stinging or burning on application"

Common Complaints

"10 mL is a very small tube for the price"

"Retinol concentration not disclosed"

"NAD+ claims feel overhyped relative to the evidence"

"Slow to show dramatic wrinkle reduction"

Notable Endorsements

Numbuzin's best-selling eye treatmentAvailable at Olive Young globally

Appears In

best eye cream for dark circles best k beauty eye cream best retinol eye cream best peptide eye cream

Related Conditions

aging dark circles dullness

Related Ingredients

retinol niacinamide peptides ceramides hyaluronic acid